“Cooper” is a 2 year-old male neutered mastiff X with severe osteoarthritis secondary to hip dysplasia in both hips, “Cooper” was reluctant to climb stairs or play with other dogs in the family and sat and stood with difficulty. He was only mildly responsive to NSAIDS. “Cooper” was treated with adult-derived mesenchymal stem cells, which were injected into both hip joints.”Cooper” showed great improvement within a month.Owners comment “A dramatic improvement in climbing stairs and now playing with other dogs.”